PHARMACEUTICAL AND BIOTECHNOLOGY INDUSTRY - Lab-Wissen

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PHARMACEUTICAL AND BIOTECHNOLOGY INDUSTRY

Protein-based drugs are the fastest growing class of drugs for the treatment of many diseases in humans, ranging from cancer to Alzheimer’s disease. Accurate viscosity values of proteins are essential in understanding behavior, designing delivery systems, and accurately determining particle size/hydrodynamic radius.

VROC® powered viscometers deliver accurate and reliable viscosity results that are required to understand behaviors of antibodies and other proteins. By applying a wide range of viscosities and shear rates, you can gain a full length range of insight into your proteins.

Remember VROC® technology :

  • Smallest sample volumes
  • Direct shear rate control
  • First principle or true viscosity

Check out all of our application notes separated into major topics:

  • Formulation
  • Protein Screening
  • Antibody Therapeutics
  • Drug Delivery
  • Protein Stability
  • RNA Therapeutics
  • Hydrodynamic Radius
  • Whole Blood/Blood Plasma/Blood Serum
  • Ophthalmic Solutions
Formulation
Protein Formulation Requires Stability & Efficacy

Working with various protein candidates, buffers, adding excipients, etc, check out the application notes that we have published that are important to formulation.

  • Formulation of Eye Drops with Shear Rate Dependence (Opthalmic Formulation)
  • Concentrated Protein Solutions - Temperature Dependent Viscosity
  • Monitoring Stability of Concentrated Protein Solutions
  • Viscosity of Thermosensitive Pharmaceutical Excipients
  • Viscosity Reduction in Protein Solutions
  • How do Your Proteins Interact?
  • Optimization of Protein Formulation Complete Viscosity Characterization of Gamma-Globulin and Serum Albumin Solutions - Viscosity Fingerprinting and Analysis
  • Automated Temperature Sweeps
  • Automated Viscosity Screening Through Temperature Sweeps
  • Automated Screening: BSA Viscosity Versus Concentration and Temperature
  • Intrinsic Viscosity Measurement for Optimal Therapeutic Formulation
  • Measurements with 18 µL of Sample
  • Sample Retrieval: 20 Different Shear Rates with 18 µL of Sample
  • Impact of Excipients on Buffer Viscosity
  • High Concentration of Biologics
  • Protein Formulation Stability Probe with VROC
  • Thermosensitive Polymers as Pharmaceutical Excipients
  • Viscosity vs. Concentration: L-Arginine Dilute Solutions in Water and PBS
  • Gamma Globulin from Bovine Blood
  • Protein Formulation Stability - Sucrose Effect
  • Rank Your Buffer - Excipient Impact on Viscosity
  • Injectability
  • The Best Practice for an Accurate Estimation of the Injection Force of Protein Therapeutics Avoiding Common Pitfalls
  • Can Your Proteins Take the Heat II
  • Shear Rate Dependency of Concentrated Protein Solutions
Protein Screening
Screening for Protein-Protein Interaction

  • Probing Microstructural Changes with Viscosity Measurements
  • How do Your Proteins Interact?
  • Intrinsic Viscosity for Optimization of Protein Therapeutics
  • Repeatable Viscosity Measurements for Protein Candidate Screening
  • Automated Temperature Sweeps
  • Automated Viscosity Screening Through Temperature Sweeps
  • Automated Screening: BSA Viscosity Versus Concentration and Temperature
  • Impact of Excipients on Buffer Viscosity
  • Thermosensitive Polymers as Pharmaceutical Excipients
  • Viscosity vs. Concentration: L-Arginine Dilute Solutions in Water and PBS
  • Protein Unfolding or Denaturation Study
  • The Best Practice for an Accurate Estimation of the Injection Force of Protein Therapeutics Avoiding Common Pitfalls
  • Can Your Proteins Take the Heat II
  • Shear Rate Dependency of Concentrated Protein Solutions

Drug Delivery
Drug Delivery Systems

Administration of a drug is not limited to one method, there are different approaches, formulations, and delivery that all contribute to efficacy. Viscosity of the formulation can impact efficacy in many different ways. Learn more:

  • Optimization of Protein Formulation Complete Viscosity Characterization of Gamma-Globulin and Serum Albumin Solutions - Viscosity Fingerprinting and Analysis
  • High Resolution Automatic Viscometer Distinguishes Injectability of Candidate Proteins at an Early Stage of Development
  • Injectability Tutorial Accurate Estimation of Injectability from High Shear Viscosity
  • The Best Practice for an Accurate Estimation of the Injection Force of Protein Therapeutics Avoiding Common Pitfalls

Hydrodynamic Radius
Characterization of Proteins

Hydrodynamic radius (Rh) is a common parameter used to describe a molecule's size. Understanding the characteristics of proteins can help understand protein behavior as proteins can be quite complex.

  • Intrinsic Viscosity Analysis of Protein Solutions
  • Can Your Proteins Take the Heat?
  • How do Your Proteins Interact?
  • Intrinsic Viscosity for Optimization of Protein Therapeutics
  • Ionic Strength Affects Protein Stability in Solution
  • Optimize Your Formulations: Intrinsic Viscosity Measurements of Protein Solutions with VROC® initium
  • Intrinsic Viscosity Measurement for Optimal Therapeutic Formulation
  • Single Point Intrinsic Viscosity
  • Intrinsic Viscosity/Hydrodynamic Radius
Whole Blood/Blood Plasma/Blood Serum
Hemodynamics

Fluid dynamics in blood flow can help understand flow behavior when it comes to diagnostics and treatment of various conditions.

  • Viscometers for Whole Blood, Plasma, and Serum
  • Canine Blood Serum Viscosity
Opthalmic Solutions
Eye Drops

Eye drops or opthalmic solutions are a good example of where shear rates are a large contributing factor.

  • Upgrade with Confidence! - High Shear Rates with VROC® initium
  • Estimate Blinking Shear Rates
  • Impact of Viscosity on Eye Drop Retention
Protein Stability
Stable Protein is the Goal

Read our application notes where we touch base on protein stability and how to prolong stability.

  • Concentrated Protein Solutions - Temperature Dependent Viscosity
  • Monitoring Stability of Concentrated Protein Solutions
  • Impact of Excipients on Buffer Viscosity
  • Can Your Proteins Take the Heat?
  • Ionic Strength Affects Protein Stability in Solution
  • Protein Formulation Stability - Sucrose Effect
  • Can Your Proteins Take the Heat II
  • Shear Rate Dependency of Concentrated Protein Solutions
RNA Therapeutics
RNA Therapies

RNA Therapies have been used for high-impact drug development. RNA Therapy plays in cellular activity and thus have been an advantage over small and large molecule compound therapies in certain ways.

  • RNA Therapeutics Viscosity
Antibody Therapeutics
Protein Therapeutics

Antibody therapeutics, an alternative method from RNA Therapeutics, is also equally viable when it comes to development combat methods against serious illnesses. See what factors will be important and what you should understand if you are in the industry.

  • Antibody Therapeutics - Monoclonal Antibodies
  • Protein Therapeutics
Cell Culture
Cell Culture Media

Cell culture media is a complex fluid composed of nutrients required for cells to grow, proliferate, and differentiate.

  • Viscosity of DMEM Cell Culture Media
  • F12 Cell Culture Media
  • Viscosity of Fetal Bovine Serum and Media Formulations
Please contact our company for more details. Our team will be very glad to support you.
 
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